In a bowl, whisk together the cream and egg until smooth.
Add ½ cup panko, Italian seasoning, garlic powder, a big pinch of crushed red pepper, and the Parmesan cheese. Mix until combined and add a pinch of salt and pepper.
Add the turkey to the bowl and season with salt and pepper. Use your hands to mix until combined, adding more panko as needed. The mixture should hold together but still be moist and not too firm.
Heat the olive oil in a wide pot over medium heat. Once hot, add a tiny drop of the meatball mixture and fry until cooked through. Taste and adjust the seasonings. Reduce the heat on the pot to low while you roll the meatballs.
Roll the mixture into 2-inch balls; you should have about 12 meatballs. If you prefer smaller meatballs, roll them into tablespoon-sized balls, and you should have about 20 meatballs.